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OTC and Herbal Products

As with any medication, cannabis may have the ability to interact, both pharmacokinetlcally and pharmacodynamically, with over-the-counter medications and herbal products. We encourage the practicing pharmacist to ask patients about their use of marijuana, particularly if selecting products that may interact with the agent.  

 

 

Agents Affected by Cannabis

Effect  OTC Agents Herbal Medications
Decreased effect

Acetaminophen-(CYP 2e1)

Loratadine


Caffeine
Increased / Potentiated effect   5-HTP

Angelica

Calamus

California poppy

Catnip

Clove

Danshen

Garlic

Ginger

Gingko

Ginseng 

Jamaican dogwood

Kava Kava

Skullcap

These increase bleeding risk:

Valerian root

Yerba Mansa

 

Agents that Affect Cannabis

 

  OTC Agents Herbal Medications
Decreased effect of Cannabis    Ginseng (inhibits 3A4)

Goldenseal

Grapeseed oil (Inhibits 3A4)

Red Yeast Rice

St. John Wort (inducer of CYP 2C9)

Increased / Potentiated effect   Grapefruit juice (inhibitor of CYP3A4)

 

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